Vasoactive intestinal polypeptide-like immunoreactive nerves in diabetic penis. A comparison between streptozotocin-treated rats and man.
نویسندگان
چکیده
Vasoactive intestinal polypeptide (VIP) has been demonstrated by immunofluorescence histochemistry in nerves in human and rat penile tissue. A reduction in VIP-like immunoreactivity in nerves was revealed in tissue from streptozotocin-diabetic rats and a human diabetic with impotence. These results suggest that an impairment in the VIP-ergic innervation in penile tissue may be an important factor in the development of impotence in diabetes. They also support the view that the streptozotocin-treated rat is a useful experimental model for diabetic autonomic neuropathy.
منابع مشابه
The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs.
The aim of the study was to investigate antioxidant (alpha-lipoic acid [LA]) and gamma-linolenic acid treatments in the prevention of changes in autonomic nerves induced in streptozotocin-diabetic rats. Autonomic nerves supplying the heart, penis, and gut were examined using immunohistochemical and biochemical techniques. LA and gamma-linolenic acid (present in evening primrose oil [EPO]) were ...
متن کاملVasoactive intestinal peptide and impotence in experimental diabetes mellitus.
OBJECTIVE To determine whether a defect in vasoactive intestinal peptide (VIP)-mediated vasodilatation underlies diabetic impotence. MATERIALS AND METHODS Rats treated with streptozotocin for 8 weeks developed diabetes, as shown by hyperglycaemia and glycosuria, and had significant impairment of sexual function, as determined by tests of sexual behavior. The VIP content of the penis and major...
متن کاملSubstance P and vasoactive intestinal polypeptide in the streptozotocin-induced diabetic rat retina.
PURPOSE Little knowledge exists about how neurotransmitters behave in the diabetic retina. In this study, the authors measured the concentration of two neuropeptides, substance P and vasoactive intestinal polypeptide, in the streptozotocin-induced diabetic rat retina in a time-dependent manner. METHODS The retinas of 1-, 3-, 5-, 8-, and 12-week diabetic rats were processed using a highly sens...
متن کاملEffect of an Antagonist of Vasoactive Intestinal Polypeptide on Biological Rhythm of Rest Activity in the Rat
Abstract Vasoactive Intestinal Polypeptide (VIP), has been found in different neurotransmitter systems and exists in various nerve tracts in the brain. Potential role of this peptide in physiological processes such as regulation of sleep and wakefulness, and biological rhythms has been confirmed in several reports. In the present research effects of intracerebroventricular (ICV) injection of a...
متن کاملThe Effect of Quinapril on the Aortic Contractile Response of Streptozotocin-Diabetic Rats
Angiotensin-converting enzyme (ACE) inhibitors appear to correct many of the abnormalities associated with the vascular dysfunction found in diabetic patients. In this respect, quinapril is a unique ACE inhibitor with multiple protective effects. The present study was carried out to investigate the effect of intraperitoneal administration of quinapril on the aortic reactivity of streptozotocin ...
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ورودعنوان ژورنال:
- Diabetes
دوره 32 11 شماره
صفحات -
تاریخ انتشار 1983